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In practice, women's health is less about finding the perfect hero nutrient and more about filling in the gaps consistently
As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
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In particular, FKBP12 is a 12-kDa cytosolic protein with peptidylprolyl cistrans isomerase activity, while FKBP-13 is a 13-kDa membrane-associated protein with 43% amino acid identity with FKBP12 (Lai et al., 2010)
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