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a) Distribution of pre-treatment weight

Blood Sugar May Go Up Since GLP-1s improve insulin resistance, inconsistent use can diminish their blood sugarlowering benefits for those with diabetes

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Within the gutbrain framework, enteroendocrine cells act as chemosensory sentinels that translate luminal cues into endocrine and paracrine signals detected by vagal afferents, providing a concrete route through which microbiota-derived signals could modulate neuroendocrine circuits relevant to therapeutic heterogeneity (68)