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Symptoms may include: pain below the kneecap discomfort during exercise stiffness after periods of rest tenderness when pressing on the tendon reduced athletic performance Because tendon tissue typically has a limited blood supply, recovery may take longer than many people expect

We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

Put the three together and the pitch is a loop: supply NAD+, protect NAD+, then flip on the pathways that spend it productively

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