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Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide ( More recent analyses suggest that spexins metabolic actions may be dissociable from its nociceptive or affective effects through receptor subtype selectivity and dosing strategies ( 4.3 Meteorin-like protein (METRNL) and exercise-induced endocrinology Meteorin-like protein (METRNL) occupies a distinct conceptual niche within metabolic peptide biology
The weight-loss revolution sparked by GLP-1 drugs like Ozempic and Mounjaro is doing more than changing waistlines its transforming the food industrys relationship with biology
The HCR-based DNA nanoframeworks facilitate the loading capability of the delivered molecules, showing notable therapeutic efficacy and biosensing sensitivity
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For example, in a controlled feeding study in healthy young men, 37% of heme iron was bioavailable compared to only 5% of non-heme iron (Bjorn-Rasmussen 1974)
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