Before prescribing semaglutide, clinicians should discuss the boxed warning in understandable terms, explaining that animal studies showed thyroid tumors but human risk remains theoretical and unproven
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GLP-1 and its analogues have been shown to possess direct effects on improving cardiomyocyte viability, cardiac function, and vasodilation
The study group included 97 adults using liraglutide, 36 receiving semaglutide, 35 using tirzepatide and 82 receiving usual care without a GLP-1-based medication