Mice were placed onto a cage hopper and infused with semaglutide, GLP-1MK-801 or vehicle (isotonic saline) over 60 s at a total infusion volume of 2 l through a Hamilton syringe mounted onto an automated syringe pump (Harvard Apparatus) and a 33-gauge internal cannula (PlasticsOne, C315IS-4/SPC, 2.5 mm)

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Diabetes Care (2004) 27:262835
GLP-1s in general a category that includes Ozempic, its higher-strength counterpart Wegovy , and others are known for causing gastrointestinal side effects that can be bothersome
That is one reason these medications have drawn attention beyond diabetes and obesity management