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In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks
The effect on systolic pressure was greater in older patients, perhaps because of greater baseline systolic pressure
Blood laboratory studies will find hypoglycemia and hyperammonemia while urinalysis will show hypoketonuria
Screening updates for fear of hypoglycemia, diabetes distress, and anxiety
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