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Regarding fat distribution specifically, research indicates that weight loss with GLP-1 receptor agonists results in reductions across multiple fat compartments, including: Visceral adipose tissue (fat surrounding internal organs in the abdomen) Subcutaneous fat (fat beneath the skin, including abdominal areas) Overall body fat percentage Imaging studies using MRI and CT scans have confirmed that semaglutide treatment leads to meaningful reductions in visceral fat, which is metabolically significant as this type of fat is associated with increased cardiovascular and metabolic risk

95 : 212221 Horsten M, Wamala SP, Vingerhoets A, Orth-Gomer K

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