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In the mechanism of gemcitabine resistance, the functional defect of nucleoside transporter hENT1 is the core factor of metabolic pathway abnormality
Allosteric pockets have the advantage of tending to be unique to the protein of interest, unlike ATP-binding pockets, so selectivity tends to be far less of a problem, which can be critical when tackling same class proteins like kinases
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While SGLT2 inhibitors do promote modest weight loss (13 kg), their effect is less pronounced than that of GLP-1RA, and they have less impact on thyroid hormone absorption [42, 43]
