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So, broader coverage in 2025 could be more likely
One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress
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The role of aldose reductase in polyol pathway: an emerging pharmacological target in diabetic complications and associated morbidities
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