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When insulin function is deficient, high levels of sugar keep circulating in the blood causing pre-diabetes

10.1016/j.ejphar.2013.08.043 97

Psychological impact weight concerns can affect self-esteem, leading to depression or anxiety that worsen ED

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For example GLP-1s are being studied for treatment of other illnesses, like cardiovascular disease, heart failure, liver disorders, and obstructive sleep apnea