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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
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(2025) The Lancet Respiratory Medicine
Similar to its analgesic action, the mechanism of antipyretic action of this drug remains poorly understood
( f-h ) (left) Relative abundance (normalized to vehicle-treated group), (middle) fractional labelling, and (right) fractional abundance normalized to vehicle treated cells of 15 N label incorporation of indicated metabolites in 14-day BCS-treated SEM cells
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