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According to the report, despite the initiation of lifestyle modifications and metformin therapy at 9 years of age, the patient showed a poor response after 1 year of treatment: his BMI increased from 46.7 to 51.2 kg/m 2 , body fat percentage worsened from 53.1% to 65%, and he continued to experience difficulty achieving satiety with nocturnal awakening due to hunger and subsequent eating

A., Novotny, E

Future developments may include the exploration of different dosages and treatment durations, as well as the investigation of combination therapies that incorporate Semaglutide with other weight loss medications or interventions

"GH secretagogues: physiological and clinical relevance." Trends in Endocrinology & Metabolism , 1997.

e.g., LEADER, SUSTAIN-6, EXSCEL, HARMONY Outcomes, REWIND, ELIXA, AMPLITUDE-O, SELECT) and other large-scale clinical programs (e.g., PIONEER, AWARD, LEAD, SCALE, STEP)