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C/EBP-dependent epigenetic memory induces trained immunity in hematopoietic stem cells

Richard Horowitz describes the Jarisch-Herxheimer (JH) flare as a temporary worsening of the symptoms of Lyme disease that occurs when the Lyme spirochete is being killed off by antibiotics, creating inflammationThese JH reactions produce cytokines (TNF-alpha, IL-6, and IL-8), which then create inflammatory symptoms, including increased fever, muscle and joint pain, headaches, cognitive impairment, and a general worsening of the underlying symptomology

Rotation Strategy Prevents Lipodystrophy and Improves Absorption Rotating injection sites weekly or with each injection reduces the risk of lipohypertrophy (thickened fatty tissue) and lipoatrophy (sunken areas), both of which can slow medication absorption

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