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This does not independently require discontinuation, but it changes the urgency of the evaluation

Tirzepatide diarrhea results from dual GLP-1 and GIP receptor activation in the intestinal tract, which slows gastric emptying, accelerates small bowel transit time, and increases fluid secretion into the gut lumen

Safety Considerations There are currently no published studies specifically examining the combination of CJC-1295 and Retatrutide in humans

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