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Novo Nordisk submitted its application to the FDA to expand the indication for Rybelsus to reduce the risk of MACE in patients with type 2 diabetes and established CVD and/or chronic kidney disease
GLP-1 receptor agonist drugs like Ozempic and Mounjaro are a major breakthrough in obesity (and possibly addiction) treatment and have rapidly become mainstream in the early 2020s
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PEGylation the conjugation of polyethylene glycol chains to the peptide extends this half-life substantially, to several hours, enabling stable receptor engagement over experimental time windows that native MGF cannot sustain
Elevated IGF-1 levels (need to be monitored)
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