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You can certainly make the case that the comparison group - insulin treatment - may put patients at higher cardiovascular risk because of the negative impact of elevated insulin levels
Low levels have been linked to many autoimmune disorders, preeclampsia, Parkinson's disease, HIV, liver disease and renal failure
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Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6
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