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[12] DSIP abundance has been observed to be lower in cerebrospinal fluid of research models of depression compared to the same controls

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In an animal high-altitude model, phosphorylated DSIP improved spatial-memory and sleep-architecture markers, but sample size was not clearly reported and this was not a healthy-human trial [11]

At the same time, a vitamin B12 deficiency is only one possible contributor toward an iron deficiency