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We therefore grouped overlapping metabolites into biochemically coherent modules across all three outcomes: one-carbon metabolism ( Figure 5A ), alternative carbon sources ( Figure 5B ), and tryptophan degradation ( Figure 5C )

By directly targeting the genes and molecular pathways involved in L-cell differentiation, gene therapy holds the potential for long-term or even permanent solutions

Substrates were added in a stepwise fashion in the following order (final concentrations) 0.2 mM palmitoyl carnitine, 1 mM malate, 4 mM ADP, 0.4 mM octanoyl carnitine, 5 mM pyruvate, 10 mM glutamate, 10 mM succinate, 1 M CCCP, 2 M rotenone, and 5 M Antimycin A

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