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Melanocortin receptor density in the hypothalamus and skin follows a circadian rhythm that makes morning dosing more efficient for melanogenesis while minimising appetite suppression interference with evening meals
Online research peptide vendors sell BPC-157 as a research chemical, not for human consumption
The injection itself is usually hydroxocobalamin, which the UK prefers over cyanocobalamin because it stays in the body longer, as set out in the BNF entry
The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
The standard initial loading dose is 1,000 mcg administered intramuscularly (IM) once weekly for 4 weeks
