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Targeting dementia prevention with semaglutide: The case for APOE4 homozygotes [PMID: 40572012] Laboratory literature summary: Targeting dementia prevention with semaglutide: The case for APOE4 homozygotes
When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
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