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The GIP receptor (GIPR), a GPCR, is primarily expressed in pancreatic -cells, where it plays a key role in insulin secretion
Mueller-Gomez, J.L
However, the timeline for visible weight loss depends on multiple factors beyond the medication itself, including your baseline metabolism, diet quality, and how your body's GLP-1 receptors respond to the compound
2,3 SURPASS-2 (NCT03987919) was a 40-week study comparing the efficacy and safety of Mounjaro 5 mg (N=470), 10 mg (N=469) and 15 mg (N=469) to injectable semaglutide 1 mg (N=468) in adults with type 2 diabetes inadequately controlled with 1500 mg/day metformin alone
10.1038/s41420-021-00660-4 152 WuY.JiaoH.YueY.HeK.JinY.ZhangJ.et al (2022)
