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Injecting close to the affected area is believed by some to provide more localized effects, though systemic distribution occurs regardless of injection site

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Mobile phase A consisted of 25 mM ammonium hydroxide and 25 mM ammonium acetate in water, while acetonitrile was used as mobile phase B

For instance, chronic high H 2 O 2 levels can activate p38 continuously, inducing melanocytes to premature senescence (dysfunctional) and susceptible to apoptosis ( FIGURE 7 Vitiligo patients have a reduced mitophagy process in epidermal melanocytes (Lotti and DErme, 2014)