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Resistance mechanisms to immune checkpoint inhibitors: updated insights
The euchromatin is characterized by an open state and is amenable to transcription, while the heterochromatin is characterized by a compact DNA-protein structure that cannot be transcribed (Jenuwein and Allis, 2001)
Low thyroid levels are particularly common among women over 60 years of age
Drugs with narrow therapeutic windows (warfarin, levothyroxine, oral contraceptives, certain seizure medications) deserve clinician oversight
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