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However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain
Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels
They also worry that when patients receive drugs online from compounding pharmacies, they may not get the same level of guidance about how to take the drugs or what to expect from the compounded drug providers as they would get from a clinician
The researchers compared the three primary B12 delivery methods and found the following mean increases in serum B12 levels: A p-value of 0.270 means there is no statistically meaningful difference between the three methods
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