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Immunohistochemistry with SOX10 (staining the cell nuclei of melanocytes) facilitates diagnosis of lentigo maligna, in this case showing an increased number of melanocytes along stratum basale of the skin, and nuclear pleomorphism
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These divergent results may be explained by impaired Toll-like receptor 4 (TLR4) (25, 53) signaling due to disruption of PAR2 heterodimer formation in the complete PAR2 knockout, whereas selective abrogation of PAR2 cleavage is known to preserve proinflammatory responses but abolishes interferon responses downstream of TLR4 signaling in innate immune cells (54, 55)
Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice
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