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While the liver was previously thought to be the main target of metformins glucose-lowering effects, recent evidence suggests that other parts of the body, such as the gastrointestinal tract, also play a role in its overall clinical advantages
The findings are published in JAMA
(74) To me, this is fascinating and makes complete sense, given the role of amino acids in neurotransmitter metabolism
The obesity and metabolic disease burden (with over a billion overweight or obese individuals worldwide) ensures continued demand
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