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As estrogen declines, body-fat distribution shifts from hips and thighs, where fat is relatively protective, to the abdomen, where it becomes visceral fat , the inflammatory type that wraps around internal organs and drives insulin resistance

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Some patients experience mild nausea that persists for 3-4 weeks before improving, while others feel better after just several days

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These properties are distinct from those of minoxidil and finasteride, which act through different mechanisms (vasodilation and inhibition of 5-alpha-reductase, respectively)