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FIGURE 8 FIGURE 9 Compound 24 exhibited various hydrophobic interactions with them, and its planar ring occupation within the active site suggested its potential as a lead molecule for further structural modification

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All animal experiments complied with the ARRIVE guidelines and were approved by the Experimental Animal Management and Use Committee and Experimental Animal Ethics Committee of Southern Medical University and complied with international animal health guidelines

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[10] [11] There is no evidence from the SmPC or major interaction databases of a specific interaction increasing NSAID-induced gastropathy risk with Rybelsus