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In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]

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Dapagliflozin, empagliflozin, and ertugliflozin are the most selective SGLT2 inhibitors (Markham and Keam, 2019), while canagliflozin can act as a dual SGLT1/2 inhibitor and is able to inhibit intestinal glucose absorption by blocking intestinal SGLT1 (Minze et al., 2018