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Based on the findings, the researchers suggest that semaglutide lowers body weight by directly interacting with diverse GLP-1R populations and directly and indirectly affecting the activity of neural pathways involved in food intake, reward, and energy expenditure
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GLP-1s also increase glucose uptake and storage in muscles and decrease hunger through multiple pathways in the brain
Ongoing development of targeted, sustained-release systems and multimodal combination strategies holds promise for improving long-term clinical outcomes and expanding access to individualized treatment
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