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Notably, the HGF transgenic mouse has ectopic extra-follicular melanocytes in trunk skin at the dermal/epidermal junction and in the epidermis 12 , thus modelling human skin more closely than most animal skin in which melanocytes at these sites are confined to the hair follicle

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Dhatariya K, Bain SC, Buse JB et al (2018) The impact of liraglutide on diabetes-related foot ulceration and associated complications in patients with type 2 diabetes at high risk for cardiovascular events: results from the LEADER trial

J Pediatr 1981

Similarly, physical and psychological stressors might also initiate the emetic cascade directly activating NTS neurons, which by projecting to the PVN in the hypothalamus might stimulate both the HPA axis and autonomic responses