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The company announced that ongoing use of semaglutide (Wegovy) led to a 57% greater reduction in the risk of heart attack, stroke, or death in people with obesity or cardiovascular disease compared with tirzepatide users
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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes
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