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They mimic a natural gut hormone called GLP-1, which is released after eating and helps coordinate metabolism in several ways: they slow how quickly food leaves the stomach, increase feelings of fullness in the brain, reduce appetite, and help the pancreas release insulin when blood sugar rises while also lowering glucagon, a hormone that tells the liver to release stored sugar

However, our findings contrast with those of other clinical studies, in which acute administration of metformin was reported to have little effect on the insulin response to a standardised test meal in individuals with type 2 diabetes [8, 14, 24]

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Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses*