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The NIH estimates that 10 to 30 percent of adults over 50 have some degree of B12 malabsorption
However, as research progressed, its therapeutic potential expanded beyond gastrointestinal applications
The pancreatic secretion of intrinsic factor is reduced or absent, secondary dysbiosis of the intestine is common, and the mucosa may be compromised by the presence of excessive bacterial numbers and toxic metabolites
That conversion depends on liver enzymes and methyl donors such as folate
E., Stone, S
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