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in the context of a balanced triple agonist, its classical effect on hepatic glucose production is offset by the simultaneous GLP-1R/GIPR insulinotropic action, while the metabolic effects that peptide designers actually want from GCGR are retained: increased energy expenditure via brown-adipose thermogenesis and skeletal-muscle oxidation, adipose lipolysis with free-fatty-acid release for beta-oxidation, and hepatic fatty-acid oxidation that clears triglyceride from the liver 27
Stored liver fat decreases
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Generic drugs must prove bioequivalence to a brand-name drug and receive specific approval from the Food and Drug Administration (FDA)
This selectivity profile makes it particularly valuable for research and therapeutic applications where targeted growth hormone stimulation is desired without unwanted hormonal side effects
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