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Endocrinology (2013) 154:48
Contrariwise, other relevant aspects, such as the safety profile and tolerability of GLP-1RA or the beneficial effects on fertility in PCOS, have been more extensively treated, especially considering that possible direct or indirect reproductive effects of GLP-1 RA might require a concomitant effective contraception and a washout period before pregnancy [22, 24,25,26,27,28,29,30,31]
A comprehensive literature search was performed in PubMed, Web of Science, Embase, and Scopus from inception to October 2025 using the keywords tirzepatide, GLP-1/GIP receptor agonist, obstructive sleep apnea, and obesity. Priority was given to randomized controlled trials, major observational studies, and relevant mechanistic research
Many people stay on the medication for 6 to 12 months, while others use it longer, taper off, or transition to another option based on what feels sustainable
18 PackerMAnkerSDButlerJFilippatosGZannadF
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