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& Pachitariu, M
As the discontinuation rates were also high with the twice daily danuglipron at the phase 2 obesity trial (as discussed above), twice daily danuglirpon formulation will not advance into phase 3 studies, but an improved once-daily formulation with an aim to improve tolerability profile is currently under assessment [27]
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It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina)
The mechanisms include improved insulin sensitivity, reduced hyperandrogenism, normalisation of leptin levels, and restoration of hypothalamic-pituitary-ovarian axis function
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