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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

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Plus, a very calorie-restricted diet can cause side effects such as gallstones, an irregular heartbeat, and low electrolytes

Presented for research literature review only Woehle DL et al

Always consult your healthcare provider before starting any new supplement regimen.