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The role of neuroinflammation and neurovascular dysfunction in major depressive disorder
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doi:10.1016/j.arr.2016.08.006
Methylmalonic acid is a compound that accumulates in the body when there is a deficiency of vitamin B12 or a functional deficiency, as seen in Pernicious Anemia
However, it remains to be determined if PTSD and mental stress directly increase the burden of cellular senescence in the vasculature and if the accumulation of senescent vascular cells is mechanistically implicated in mental stress-induced vascular aging
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