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35,36 Although some studies report smaller reductions in muscle mass, many scientists argue that these findings should not be ignored due to the high metabolic rate of skeletal muscle which plays an important role in maintaining significant weight loss

The April 2026 TGA alert regarding unapproved GLP-1 receptor agonists (including Retatrutide) reinforced the distinction between therapeutic use, which remains unapproved, and research-grade supply for laboratory purposes, which is legally distinct under Australian law

Potent GLP-1 agonists exert effects by multiple mechanisms including delayed gastric emptying, increased glucose-dependent insulin secretion, reduced glucagon levels, and reduced food intake by CNS effects to cause appetite suppression

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