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The 2020 International Society of Hypertension (ISH) Global Practice Guidelines state that "de-escalation of antihypertensive treatment may be considered in patients who have achieved sustained blood pressure control, particularly after addressing lifestyle factors." The guidelines emphasize that de-escalation should be accompanied by "regular follow-up and home blood pressure monitoring." At each step, check your blood pressure at least twice daily (morning and evening) using a validated upper-arm cuff

Skattum, L., Martensson, U

However, people with severe allergies, particularly MCAS, may be more reactive to any new substance

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DSIP may cause drowsiness