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Yes, the two are commonly combined

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Of note, studies of mice have found that while mice gain weight when placed under chronic stress and given a high-fat diet, they gain more weight when given antidepressants as well in the context of an already unhealthy lifestyle

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CoQ10 functions as a highly mobile shuttle, actively transporting high-energy electrons from Complex I (NADH dehydrogenase) and Complex II (succinate dehydrogenase) and delivering them to Complex III (cytochrome bc1 complex)