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Conversely, SLC19A1 overexpression in activated T cells enhanced p-AKT and NOTCH1 signaling activation (Supplementary Fig
(iii) Most importantly, TMAO may be just one of many factors that influence atherosclerosis and its complications
For the epigenetic dysregulation subtype, the priority is to use epigenetic drugs in combination with SSP inhibitors, such as m6A inhibitors plus PHGDH inhibitors, to abrogate the aberrant activation of genes encoding key SSP metabolic enzymes at the source
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