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A standard 16-week protocol following the 2mg, 4mg, 8mg, 12mg escalation requires approximately 104mg total

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doi: 10.3389/fmed.2026.1783429 Received 10 January 2026 Revised 20 April 2026 Accepted 30 April 2026 Published 28 May 2026 Volume 13 - 2026 Edited by Achuthan Raghavamenon, Amala Cancer Research Centre, India Reviewed by Raffaele Carraro, La Princesa University Hospital, Spain Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Updates Copyright 2026 Wu, Zhang, Ye, Chen, Tung and Zhu