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The brainstem, which has been implicated to be affected in PASC, explaining the broad spectrum of symptoms, particularly pain and autonomic symptoms [156], has been found to show glucose hypometabolism in patients (among other regions) [47, 53, 89]
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Neither spinalization nor bilateral transection of pelvic or dorsal penile nerves impaired the facilitator activity of intravenous Melanotan II, but removal of the lumbar paravertebral sympathetic chain abolished the effect, indicating recruitment of both central and peripheral melanocortin pathways depending on route of delivery
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