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All currently marketed anti-diabetic drugs targeting DPP-4 block substrate binding by making hydrogen bonds with the anchoring residues Glu205/Glu206 and occupying the S1 hydrophobic pocket (Figure 7)
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This is not a casual decision
This temporary discomfort is generally outweighed by the long-term benefits of reaching the optimal therapeutic dose
If you notice any of the following, tell your doctor immediately: Common side effects: burping, nausea, vomiting, diarrhoea, constipation and abdominal pain
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