The NHS does not set an upper safe limit for B12 because harmful effects from excessive intake have not been definitively established
Similar trials are assessing GLP-1RAs in overweight patients with IBD (110), in UC (NCT06937086), and exploring dual GLP-1/GIP agonists like Zepbound as adjunctive therapies (NCT06774079) (112)
The most useful next step is usually a candid review of treatment fit, not a rushed decision based on convenience alone
In the present study, DCFH fluorescence levels were consistently higher in the VPA group compared to the CT group in the cerebellum, hippocampus, posterior cortex, and striatum, indicating increased oxidative stress and supporting the effectiveness of the VPA-induced animal model
European Journal of Clinical Pharmacology., 1996