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Folate binds to the catalytic domain and by altering the interaction between the regulatory and catalytic domain could stabilise the binding of FAD to MTHFR and slow down the rate of flavin dissociation (Guenther et al
has received research support for the University of Florida as principal investigator from Boehringer Ingelheim, Echosens, Inventiva, LabCorp and Perspectum and has served as a consultant for Aligos Therapeutics, Arrowhead, AstraZeneca, 89bio, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Prosciento, Sagimet Biosciences, Siemens USA and Terns Pharmaceuticals
If these side effects become too bothersome, the medication may need to be stopped
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