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Glucagon-like peptide-1 receptor agonist prevented the progression of hepatocellular carcinoma in a mouse model of nonalcoholic Steatohepatitis
Their guidelines help contextualize where tirzepatide fits within comprehensive obesity treatment algorithms including lifestyle intervention, behavioral therapy, pharmacotherapy, and bariatric surgery
J Am Coll Nutr 10: 1-12
Molecular Properties Property Value Systematic Name Aib-His-D-2-Nal-D-Phe-Lys-NH Molecular Formula CHNO Molecular Weight 711.85 Da CAS Number 170851-70-4 Structure Class Synthetic pentapeptide Receptor Target GHS-R1a (growth hormone secretagogue receptor type 1a) Development Novo Nordisk (NNC 26-0161) The sequence includes -aminoisobutyric acid (Aib) at position 1, D-2-naphthylalanine (D-2-Nal) at position 3, and D-phenylalanine (D-Phe) at position 4
Dulaglutide (Trulicity) A weekly injection approved in 2014, at 0.75 mg to 4.5 mg, with cardiovascular-outcomes data
